Bone tissue engineering: from bench to bedside

Bone Tissue Engineering: Problems Facing a Bench-Side to Bedside Solution

The field of tissue engineering has expanded at a staggering rate. In terms of bone tissue engineering research alone this has been represented by a dozen or so manuscripts being published in 1990, increasing to almost 18,000 at the time of writing. This is compounded by the fact that the tissue engineering market is estimated to be approximately 90 billion USD by 2016 [1]. Even so, the leap fr...

From bench to bedside

Because the microcirculation has emerged as an important reanimation target, appropriate methods to monitor the microcirculatory function are crucial. Several teams have now succeeded in crossing this bridge from bench to bedside, but the choice of the tissues of interest remains a debate. The potential accessible vascular beds that doctors could use in reanimation strategies and the relationsh...

From Bench to Bedside

Since the initial experiments nearly a decade ago, remarkable progress has been made in the field of vascular gene transfer, and trials with human subjects already are under way. The potential of vascular wall gene transfer as therapy for various vascular diseases is considerable.1,2 The purpose of this review is 2-fold: (1) to delineate the methods and principles underlying vascular gene trans...

Molecular Engineering of Orthopaedic Implants: from Bench to Bedside

Molecular engineering of an orthopaedic implant: from bench to bedside.

The use of metallic implants has revolutionised the practice of orthopaedic surgery. While the safety and biocompatibility of these devices are excellent, a small percentage becomes infected. These infections are due to the formation of a biofilm that harbours bacteria encased in a complex extracellular matrix. The matrix serves as a barrier to immune surveillance as well as limiting the biocid...